Recasting Human Vδ1 Lymphocytes in an Adaptive Role

Clonal selection in the human Vδ1 T cell repertoire indicates γδ TCR-dependent adaptive immune surveillance

γδ T cells are considered to be innate-like lymphocytes that respond rapidly to stress without clonal selection and differentiation. Here we use next-generation sequencing to probe how this paradigm relates to human Vδ2neg T cells, implicated in responses to viral infection and cancer. The prevalent Vδ1 T cell receptor (TCR) repertoire is private and initially unfocused in cord blood, typically...

Recasting a Scene Adaptive Video Coder for Real Time Implementation

The Scene Adaptive Video Coder is a new algorithm used to code video sequences at very low bitrates (8 kb/s to 40 kb/s). It is a constant bitrate, constant frame rate encoder. Low rates are obtained through the use of sub-pel motion estimation, aggressive adaptive vector quantization, and dynamic bit allocation. Unfortunately, the algorithm is too complex to be implemented in real time, which i...

Analysis of Vδ1 T cells in clinical grade melanoma-infiltrating lymphocytes

γδ T cells, including Vδ1 and Vδ2 T cells, can recognize tumor-associated ligands neglected by conventional αβ T cells in a MHC-independent manner. Little is known regarding the anticancer potential and the possibility to isolate and expand Vδ1 T cells to therapeutically relevant numbers. In this study, we have detected low frequencies of Vδ1 T cells among tumor-infiltrating lymphocyte (TIL) pr...

Variablity of chromosomal radioadaptive response in human lymphocytes.

Background : There are growing evidences for chromosomal radioadaptive response in human lymphocytes . Highly variable inter- and intra-individual responses have been reported. Some individuals are non-responders and even in some donors the frequency of chromatid aberrations induced by a challenge dose increases by pre-exposure to an adapting dose. It has been proposed that the lack of radioada...

Recasting the Role of Mental Disability in Criminal Cases